Taofeeq Garuba

RESEARCH, TEACHING, or OTHER INTERESTS

Plant Science, General Agricultural and Biological Sciences

FUTURE PROJECTS

Scopus Publications

Unveiling the therapeutic significance of shikimate pathway-derived phenolic acids against penicillin-binding protein 3 of Pseudomonas aeruginosa
Yamkela Dweba, Christiana E. Aruwa, Taofeeq Garuba, and Saheed Sabiu
Informa UK Limited



Molecular Characterization of Potential Crop Pathogens Associated with Weeds as Endophytes in Uniilorin Plantations, Nigeria
A. A. Lateef, T. Garuba, K. A. Abdulkareem, B. U. Olayinka, G. S. Olahan, S. B. Adeyemi, and K. A. Abdulkareem
College of Science for Women
Crop diseases are usually caused by inoculum of pathogens which might exist on alternate hosts or weeds as endophytes. These endophytes, cum pathogens, usually confer some beneficial attributes to these weeds or alternate hosts from protection against herbivores, disease resistance, stress tolerance to secondary metabolites production. This study was therefore carried out to isolate potential crop pathogens which exist as endophytes on weed species in the University of Ilorin plantations. Green asymptomatic leaves were collected from 10 weed species across the plantations, and processed for their endophytic fungi isolation. Isolates were purified into pure cultures and used for molecular identification using the internal transcribed spacer (ITS) region of the ribosomal DNA. Phylogenetic analysis of the fungal sequences using MEGA software revealed 9 fungal genera belonging to 13 species, with species in the genera Curvularia, Epicoccum and Daldinia occurring in more than one weed species, while other genera such as Alternaria, Fusarium, Chaetomium, Macrophomina, Arthrinium and Phomopsis occurred in just one weed species each. Daldinia eschscholtzii was isolated in this study as an endophyte from Loudetia arundinacea for the first time. This plant is very abundant in Nigeria and Africa where it is used majorly for thatching and feeding livestocks. This also represents the first endophytic fungi from the genus Loudetia. Potential relationship between the occurrences of these fungi as endophytes and as pathogens are discussed. These discoveries represent the first large-scale molecular identification and several first reports of endophytes from these weed species. These results also represent the first records of some of these fungi in Nigeria.


Metabolites profiling and molecular docking identification of putative leads from endophytic Phyllosticta capitalensis as modulators of key druggable structural targets of rotavirus A
Taofeeq Garuba, Rayhaan Govender, Habibah Abdulsalam Isah, and Saheed Sabiu
Informa UK Limited
Rotavirus-induced gastroenteritis is a global health concern and the leading cause of death in low-income countries and children under the age of five. While rotavirus A (RVA) vaccines are available, there accessibility and efficacy remain challenging, especially in the third world countries. This has necessitated the need to develop therapeutics to manage RVA infection. This study investigated gas chromatography-mass spectrometry-derived Phyllosticta capitalensis metabolites as potential therapeutics against the key structural proteins [VP8* portion of the VP4 (spike protein), the VP7 (capsid protein), and the VP1 (RNA-dependent RNA polymerase)] of RVA using molecular docking and ADME approaches. The results revealed that four [lup-20(29)-en-one, A’-neogammacer-22(29)-ene, stigmasta-4,7,22-trien-3-α-ol, and fucosterol] of the 67 metabolites had favourable affinity for the three structural proteins and belonged to classes of metabolite of antiviral importance. Further analysis and pharmacokinetic profiling showed that the pentacyclic triterpenoids, lup-20(29)-en-one and A’-neogammacer-22(29)-ene, had the potential to be developed as antivirals against RVA infection and effort is underway in this direction.


Resistivity of ten Nigerian Guinea Savannah Timbers to Lentinus sajor-caju, Sclerotium rolfsii, and Subterranean Termites
Nusirat A. Sadiku, , Taofeeq Garuba, Azeez Adebola Lateef, , and
AVES Publishing Co.



Nature of hematopoietic system alteration and organ damage induced by fungal filtrate of Pestalotiopsis microspora in vivo
Garuba Taofeeq, Lateef Adebola Azeez, Atunwa Soliu Abiola, Lateef Abibat Yetunde, Kolawole Olajumoke Oluwabunmi, and Sabiu Saheed
Journal of Applied Pharmaceutical Science
Taofeeq Garuba1, Adebola Azeez Lateef1, Soliu Abiola Atunwa2, Abibat Yetunde Lateef1, Olajumoke Oluwabunmi Kolawole1, Saheed Sabiu3* 1Department of Plant Biology, University of Ilorin, Ilorin, Nigeria. 2Department of Pharmacology and Toxicology, University of Ilorin, Ilorin, Nigeria. 3Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban, South Africa.


An appraisal of the metabolites, pharmacological and biotechnological significance of edible mushrooms
Tolulope Bolaniran, Abdullahi Temitope Jamiu, Taofeeq Garuba, Alhassan Muhammad Wudil, Henry Ademola Adeola, and Saheed Sabiu
Informa UK Limited
Mushrooms are universally valued for their dietary and therapeutic significance. Their importance could be attributed to numerous nutritive and dietary substances including polysaccharides, terpenoids, phenolics and other light molecular bioactive compounds. These compounds offer optimal health benefits and have been identified as a potential source of nutritional and medicinal products against several debilitating and food-related disorders. Here, we present an updated synopsis of the medicinal attributes of mushrooms, while also highlighting the technological advancements in their cultivation that have led to the birth of engineered species with improved traits that could alleviate malnourishment and contribute towards food security, offer health benefits, and provide efficient ways of waste management.


Flour functionality, physicochemical and sensory properties of steamed and baked maize meal enriched with defatted soybean
Samson A. Oyeyinka, Adedoyin I. Adebayo, Adewumi T. Oyeyinka, Ahmed O. Akeem, Taofeeq Garuba, and Adebola O. Oladunjoye
Hindawi Limited



Comparative biodiversity assessment of weed species in monocropping plantations of University of Ilorin, Nigeria




Morphology, growth variability and chemical composition of Indian and Nigerian accession of ocimum species grown in India
N. Patel, N. Patel, Sweta M Patel, R. Ingalhalli, T. Garuba, A. Ahmed, S. Oyeyinka and R. Krishnamurthy
Technical University of Cluj Napoca
https://doi.org/10.34302/2019.11.4.6 Article history: Received: 17 June 2019 Accepted: 25 October 2019 ABSTRACT Demand for medicinal plants is increasing by the day, due to their health benefits. In this study, the morphological attributes, proximate, mineral and phytochemical compositions of Indian accessions of Ocimum sanctum and Ocimum gratissimum as well as that of Ocimum gratissimum (Nigerian accession) grown in India under greenhouse conditions were investigated. Ocimum leaves showed significant variations in their morphometric attributes and these attributes increased with increasing days after planting. The leaves were good sources of fibre and relatively low in protein. O. sanctum showed superior iron content than the other species. Total phenolic and cardiac glycoside contents of the three leaves were very similar but they showed significant variations in their saponins, tannins, flavonoids and alkaloid contents. PCA revealed that Indian accessions of O. sanctum and O. gratissimum are distinctly separated and different from Nigerian accession of O. gratissimum in morphometric data and phytochemical constituents. Nigerian accession had superior phytochemical contents than the Indian accessions and may be further explored for breeding purposes to complement the Indian accessions for enhanced applications in the pharmaceutical industry in India.


Membrane stabilization and probable mechanisms of hypoglycemic activity of fruit extract of Solanum incanum L. (Solanaceae)
S. Sabiu, E. O. Ajani, R. A. Aladodo, T. Garuba, M. O. Agunbiade, A. A. Alimi, N. Lekena, and M. Abdulrazaq
Springer Science and Business Media LLC



Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata
Saheed Sabiu, Taofeeq Garuba, Taofik Olatunde Sunmonu, AbdulHakeem O. Sulyman, and Nurain O. Ismail
Informa UK Limited
Abstract Context: Spondias mombin Linn (Anacardiaceae) and Ficus exasperata Valh (Moraceae) are botanicals with known phytotherapeutic potentials in the traditional system of medicine in the world. Objective: The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats. Materials and methods: Ulceration was induced by a single oral administration of indomethacin (30 mg/kg body weight (b.w.)). Ulcerated rats were orally administered with esomeprazole (a reference drug) at a dose of 20 mg/kg body weight, and Spondias mombin and Ficus exasperata at a dose of 100 and 200 mg/kg b.w. once daily for 21 d after ulcer induction. Gastric secretions and antioxidant parameters were thereafter evaluated. Results: The significantly increased (p < 0.05) ulcer index, gastric volume, malondialdehyde level, and pepsin activity by indomethacin were effectively reduced by 65.40, 36.47, 45.71, and 53.79%, respectively, following treatment with F. exasperata at 200 mg/kg b.w. S. mombin at this regimen also attenuated these parameters by 71.70, 46.62, 50.16, and 55.73%. Moreover, the extracts significantly increase the reduced activity of superoxide dismutase as well as pH and mucin content in the ulcerated rats. Discussion and conclusion: These findings are indicative of gastroprotective and antioxidative potentials of the extracts which is also evident in the degree of % inhibition against ulceration. The available data in this study suggest that the extracts proved to be capable of ameliorating indomethacin-induced gastric ulceration and the probable mechanisms are via antioxidative and proton pump inhibition.


Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata
Saheed Sabiu, Taofeeq Garuba, Taofik Sunmonu, Emmanuel Ajani, Abdulhakeem Sulyman, Ismaila Nurain, and Abdulazeez Balogun
Elsevier BV

RECENT SCHOLAR PUBLICATIONS

Unveiling the therapeutic significance of shikimate pathway-derived phenolic acids against penicillin-binding protein 3 of Pseudomonas aeruginosa
Y Dweba, CE Aruwa, T Garuba, S Sabiu
Egyptian Journal of Basic and Applied Sciences 11 (1), 685-706 2024



Molecular Identification of Dominant Microbes in Kola nut (Cola nitida)
T Garuba, FA Ajala, GS Olahan, AA Lateef
BADEGGI JOURNAL OF AGRICULTURAL RESEARCH AND ENVIRONMENT 6 (1), 13-24 2024



New records of fungal endophytes from Unilorin Sugarcane plantation using internal transcribed spacer gene sequences
AA Lateef, T Garuba, KA Abdulkareem, BU Olayinka, GS Olahan, ...
Science World Journal 19 (4), 945-950 2024



ANTI-TOXIC PRINCIPLES FROM MUSA SAPIENTUM AND MORINGA OLEIFERA AMELIORATED SKIN HISTO-PATHOLOGY, DECREASED LIPID PEROXIDATION AND PROMOTED MELATONIN/TNF-ALPHA/P53-MEDIATED
A Akinlolu, MO Ameen, AO Oyewopo, RE Kadir, P Nwogu, M Saad, ...
Malaysian Journal of Pharmaceutical Sciences 22 (1), 43-59 2024



Assessment of Postharvest Handling of Banana Fruits and Associated Fungi in Ganmo Market, Kwara State, Nigeria
T Garuba, B Atolagbe, RA Yusuff, BY Lawal, TJ Ishola
Jewel Journal of Scientific Research 8 (1 & 2) 2023



Antitoxic Principles from Moringa oleifera (Mo11) and Musa sapientum (Ms06) Ameliorated Cadmium Chloride-Induced Renal Hyperplasia and Apoptosis through Ki67/P53-Mediated
A Akinlolu, M Ameen, G Ebito, N Asogwa, R Akindele, B Fagbohunka, ...
CHRISMED Journal of Health and Research 10 (2), 136-141 2023



Haematological, serum biochemical and histopathological changes in acute and sub-chronic aqueous extract of oyster mushroom in male Wistar rats
T Garuba, IT Olabanji, OM Awogboro, GS Olahan, SA Atunwa, OA Ahmed, ...
Journal of Scientific Research 15 (1), 201-213 2023



Effects of Different Carbon and Nitrogen Sources on the Biomass of Molecularly Identified Fungi Associated with Fruit Rot of Tomato
T Garuba, OT Mustapha, GP Oyeyiola
Journal of the University of Ruhuna 10 (1) 2022



Molecular Characterization of Potential Crop Pathogens Associated with Weeds as Endophytes in Uniilorin Plantations, Nigeria
AA Lateef, T Garuba, KA Abdulkareem, BU Olayinka, GS Olahan, ...
Baghdad Science Journal 19 (6), 1201-1201 2022



Metabolites profiling and molecular docking identification of putative leads from endophytic Phyllosticta capitalensis as modulators of key druggable structural
T Garuba, R Govender, HA Isah, S Sabiu
Transactions of the Royal Society of South Africa 77 (3), 207-217 2022



Structural And Phytochemical Characterization of Bioactive Components of the Endophytic Fungi (Trichoderma Harzianum) Extracts
OM Ameen, T Garuba, MF Zubair, MT Baker, BZ Arowolo, AO Yakubu
Journal of Applied Sciences and Environmental Management 26 (4), 689-693 2022



MICROBIAL LOAD AND MOLECULAR CHARACTERIZATION OF FUNGI ASSOCIATED WITH SWEET PEPPER (CAPSICUM ANNUUM L.) DURING STORAGE
T Garuba, AA Lateef, GS Olahan
Institute of Biology, Bucharest 2022



Effects of storage conditions and packaging materials on the fruit quality of sweet pepper (Capsicum annuum L.)
T Garuba, BY Lawal, OA Abiodun, SA Oyeyinka
Science World Journal 17 (4), 542-548 2022



PHYTOCHEMICAL SCREENING, ANTI-OXIDANT AND ACTIVITIES OF FRACTIONATED ETHANOLIC EXTRACT OF Moringa Oleifera LEAVE
OM Ameen, AA Akinolu, T Garuba, GE Ebito, BZ Arowolo, EO Oyebanji
Journal of Chemical Society of Nigeria 46 (6) 2021



Antibacterial activity of Urena lobata against uropathogens
T Garuba, N Katrodiya, N Patel, S Patel, DP Rajani, SS Chettiar, ...
Nigerian Journal of Natural Products and Medicine 25 (1), 43-46 2021



An appraisal of the metabolites, pharmacological and biotechnological significance of edible mushrooms
T Bolaniran, AT Jamiu, T Garuba, AM Wudil, HA Adeola, S Sabiu
Transactions of the Royal Society of South Africa 76 (3), 257-272 2021



Nature of hematopoietic system alteration and organ damage induced by fungal filtrate of Pestalotiopsis microspora in vivo
T Garuba, AA Lateef, SA Atunwa, AY Lateef, OO Kolawole, S Sabiu
Journal of Applied Pharmaceutical Science 11 (3), 084-091 2021



Available online: www. ncribjare. org
OO Lawal, TM Yusuf, OM Aliyu, A Olowoake, SK Subair, NB Nofiu
2021



Hepatoprotective and Anticancer Potentials ofMoringa oleifera and Musa sapientum> Extracts against Cadmium Chloride Induced Hepatotoxicity in Rats
A Akinlolu, M Ameen, G Ebito, N Asogwa, R Akindele, B Fagbohunka, ...
East and Central African Journal of Pharmaceutical Sciences 24 (3), 103–110 2021



Resistivity of ten Nigerian Guinea Savannah Timbers to Lentinus sajor-caju, Sclerotium rolfsii, and Subterranean Termites
NA Sadiku, T Garuba, AA Lateef
Istanbul University, Cerrahpasa 2021

MOST CITED SCHOLAR PUBLICATIONS

Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata
S Sabiu, T Garuba, T Sunmonu, E Ajani, A Sulyman, I Nurain, A Balogun
Toxicology reports 2, 261-267 2015
Citations: 201



Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata
S Sabiu, T Garuba, TO Sunmonu, AHO Sulyman, NO Ismail
Pharmaceutical biology 54 (1), 180-186 2016
Citations: 64



Isolation and identification of fungi involved in the post-harvest spoilage of guava (Psidium guajava) in Awka metropolis
JE Amadi, P Nwaokike, GS Olahan, T Garuba
Int. J. Eng 4 (10), 7-12 2014
Citations: 60



Effects of fungal filtrates on seed germination and leaf anatomy of maize seedlings (Zea mays L., Poaceae)
T Garuba, AA AbdulRahaman, GS Olahan, KA Abdulkareem, JE Amadi
Journal of Applied Sciences and Environmental Management 18 (4), 662-667 2014
Citations: 32



Shelf life and proximate composition of tomato (Solanum lycopersicum L.) fruits as influenced by storage methods
T Garuba, OT Mustapha, GP Oyeyiola
Ceylon Journal of Science 47 (4) 2018
Citations: 29



Proximate Composition and Chemical Profiles of Reishi Mushroom (Ganoderma lucidum (Curt: Fr.) Karst)
T Garuba, GS Olahan, AA Lateef, RO Alaya, M Awolowo, A Sulyman
Journal of Scientific Research 12 (1), 103-110 2020
Citations: 28



Influence of substrates on the nutritional quality of Pleurotus pulmonarius and Pleurotus ostreatus
T Garuba, KA Abdukkareem, IA Ibrahim, OI Oyebamiji, OA Shoyooye, ...
Ceylon Journal of Science 46 (1) 2017
Citations: 23



Combined administration of Spondias mombin and Ficus exasperata leaf extracts stall Indomethacin-mediated gastric mucosal onslaught in rats.
S Saheed, SA Olarewaju, G Taofeeq, ST Olatunde, AA Alanamu
African journal of traditional, complementary and alternative medicines 12 2015
Citations: 20



Aeropalynological investigation of the University of Ilorin, Ilorin, Nigeria
A Abdulrahaman, OS Aruofor, T Garuba, OS Kolawole, GS Olahan, ...
Journal of Applied Sciences and Environmental Management 19 (1), 53-63 2015
Citations: 16



Rhizosphere and non-rhizosphere soil mycoflora of Corchorus olitorius (Jute)
GS Olahan, IO Sule, T Garuba, YA Salawu
Science World Journal 11 (3), 23-26 2016
Citations: 11



Effect of plant extracts on sporulation and spore germination of stored melon seed fungi
JE Amadi, EE Adeleke, G Olahan, T Garuba, MO Adebola
INTERNATIONAL JOURNAL of RESEARCH-GRANTHAALAYAH A knowledge Repository 1 (1 2014
Citations: 11



Flour functionality, physicochemical and sensory properties of steamed and baked maize meal enriched with defatted soybean
SA Oyeyinka, AI Adebayo, AT Oyeyinka, AO Akeem, T Garuba, ...
Journal of Food Processing and Preservation 44 (4), e14389 2020
Citations: 9



Isolation and molecular identification of dominant fungal endophytes from green leaves of physic nut (Jatropha curcas) from unilorin plantation, Ilorin, Nigeria
AA Lateef, T Garuba, G Sa’ad, M Olesin, GG Eperetun, BB Tiamiyu
Sri Lankan Journal of Biology 4 (1) 2019
Citations: 8



Germination of several groundnut cultivars in relation to incidence of fungi
O Ahmed, BU Olayinka, T Garuba, J Ahmed, EO Etejere
Science World Journal 12 (1), 38-41 2017
Citations: 8



An appraisal of the metabolites, pharmacological and biotechnological significance of edible mushrooms
T Bolaniran, AT Jamiu, T Garuba, AM Wudil, HA Adeola, S Sabiu
Transactions of the Royal Society of South Africa 76 (3), 257-272 2021
Citations: 7



A study on endophytic fungi, proximate and chemical compositions of a local variety of mango fruit (Mangifera indica L.)
T Garuba, BU Olayinka, KA Abdulkareem, MO Bello, AA Hamid, ...
Journal of the University of Ruhuna 6 (2) 2018
Citations: 6



Membrane stabilization and probable mechanisms of hypoglycemic activity of fruit extract of Solanum incanum L. (Solanaceae)
S Sabiu, EO Ajani, RA Aladodo, T Garuba, MO Agunbiade, AA Alimi, ...
Comparative Clinical Pathology 27, 1611-1619 2018
Citations: 6



Studies on the morphology and phytochemical constituents of Dipcadi filamentosa in two states of North-Central Nigeria
KA Abdulkareem, T Garuba, R Abdulrasaq, OT Mustapha
Journal of Chemical, Biological and Physical Sciences (JCBPS) 4 (3), 2158 2014
Citations: 6



Metabolites profiling and molecular docking identification of putative leads from endophytic Phyllosticta capitalensis as modulators of key druggable structural
T Garuba, R Govender, HA Isah, S Sabiu
Transactions of the Royal Society of South Africa 77 (3), 207-217 2022
Citations: 5



In vitro cytotoxicity and antioxidant activities of Pestalotiopsis microspora culture filtrate
T Garuba, S Sabiu, AA Lateef, AT Adekanmbi, MK Adekanmbi
Malaysian Journal of Applied Sciences 3 (1), 24-33 2018
Citations: 5