Taofeeq Garuba
@unilorin.edu.ng
Lecturer, Faculty of Life Sciences
University of Ilorin
RESEARCH, TEACHING, or OTHER INTERESTS
Plant Science, General Agricultural and Biological Sciences
FUTURE PROJECTS
Secondary metabolites in mushrooms
Applications Invited
collaborator
Taxonomy of fungi
Applications Invited
collaborator
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Yamkela Dweba, Christiana E. Aruwa, Taofeeq Garuba, and Saheed Sabiu
Informa UK Limited
A. A. Lateef, T. Garuba, K. A. Abdulkareem, B. U. Olayinka, G. S. Olahan, S. B. Adeyemi, and K. A. Abdulkareem
College of Science for Women
Crop diseases are usually caused by inoculum of pathogens which might exist on alternate hosts or weeds as endophytes. These endophytes, cum pathogens, usually confer some beneficial attributes to these weeds or alternate hosts from protection against herbivores, disease resistance, stress tolerance to secondary metabolites production. This study was therefore carried out to isolate potential crop pathogens which exist as endophytes on weed species in the University of Ilorin plantations. Green asymptomatic leaves were collected from 10 weed species across the plantations, and processed for their endophytic fungi isolation. Isolates were purified into pure cultures and used for molecular identification using the internal transcribed spacer (ITS) region of the ribosomal DNA. Phylogenetic analysis of the fungal sequences using MEGA software revealed 9 fungal genera belonging to 13 species, with species in the genera Curvularia, Epicoccum and Daldinia occurring in more than one weed species, while other genera such as Alternaria, Fusarium, Chaetomium, Macrophomina, Arthrinium and Phomopsis occurred in just one weed species each. Daldinia eschscholtzii was isolated in this study as an endophyte from Loudetia arundinacea for the first time. This plant is very abundant in Nigeria and Africa where it is used majorly for thatching and feeding livestocks. This also represents the first endophytic fungi from the genus Loudetia. Potential relationship between the occurrences of these fungi as endophytes and as pathogens are discussed. These discoveries represent the first large-scale molecular identification and several first reports of endophytes from these weed species. These results also represent the first records of some of these fungi in Nigeria.
Taofeeq Garuba, Rayhaan Govender, Habibah Abdulsalam Isah, and Saheed Sabiu
Informa UK Limited
Rotavirus-induced gastroenteritis is a global health concern and the leading cause of death in low-income countries and children under the age of five. While rotavirus A (RVA) vaccines are available, there accessibility and efficacy remain challenging, especially in the third world countries. This has necessitated the need to develop therapeutics to manage RVA infection. This study investigated gas chromatography-mass spectrometry-derived Phyllosticta capitalensis metabolites as potential therapeutics against the key structural proteins [VP8* portion of the VP4 (spike protein), the VP7 (capsid protein), and the VP1 (RNA-dependent RNA polymerase)] of RVA using molecular docking and ADME approaches. The results revealed that four [lup-20(29)-en-one, A’-neogammacer-22(29)-ene, stigmasta-4,7,22-trien-3-α-ol, and fucosterol] of the 67 metabolites had favourable affinity for the three structural proteins and belonged to classes of metabolite of antiviral importance. Further analysis and pharmacokinetic profiling showed that the pentacyclic triterpenoids, lup-20(29)-en-one and A’-neogammacer-22(29)-ene, had the potential to be developed as antivirals against RVA infection and effort is underway in this direction.
Nusirat A. Sadiku, , Taofeeq Garuba, Azeez Adebola Lateef, , and
AVES Publishing Co.
Garuba Taofeeq, Lateef Adebola Azeez, Atunwa Soliu Abiola, Lateef Abibat Yetunde, Kolawole Olajumoke Oluwabunmi, and Sabiu Saheed
Journal of Applied Pharmaceutical Science
Taofeeq Garuba1, Adebola Azeez Lateef1, Soliu Abiola Atunwa2, Abibat Yetunde Lateef1, Olajumoke Oluwabunmi Kolawole1, Saheed Sabiu3* 1Department of Plant Biology, University of Ilorin, Ilorin, Nigeria. 2Department of Pharmacology and Toxicology, University of Ilorin, Ilorin, Nigeria. 3Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban, South Africa.
Tolulope Bolaniran, Abdullahi Temitope Jamiu, Taofeeq Garuba, Alhassan Muhammad Wudil, Henry Ademola Adeola, and Saheed Sabiu
Informa UK Limited
Mushrooms are universally valued for their dietary and therapeutic significance. Their importance could be attributed to numerous nutritive and dietary substances including polysaccharides, terpenoids, phenolics and other light molecular bioactive compounds. These compounds offer optimal health benefits and have been identified as a potential source of nutritional and medicinal products against several debilitating and food-related disorders. Here, we present an updated synopsis of the medicinal attributes of mushrooms, while also highlighting the technological advancements in their cultivation that have led to the birth of engineered species with improved traits that could alleviate malnourishment and contribute towards food security, offer health benefits, and provide efficient ways of waste management.
Samson A. Oyeyinka, Adedoyin I. Adebayo, Adewumi T. Oyeyinka, Ahmed O. Akeem, Taofeeq Garuba, and Adebola O. Oladunjoye
Hindawi Limited
N. Patel, N. Patel, Sweta M Patel, R. Ingalhalli, T. Garuba, A. Ahmed, S. Oyeyinka and R. Krishnamurthy
Technical University of Cluj Napoca
https://doi.org/10.34302/2019.11.4.6 Article history: Received: 17 June 2019 Accepted: 25 October 2019 ABSTRACT Demand for medicinal plants is increasing by the day, due to their health benefits. In this study, the morphological attributes, proximate, mineral and phytochemical compositions of Indian accessions of Ocimum sanctum and Ocimum gratissimum as well as that of Ocimum gratissimum (Nigerian accession) grown in India under greenhouse conditions were investigated. Ocimum leaves showed significant variations in their morphometric attributes and these attributes increased with increasing days after planting. The leaves were good sources of fibre and relatively low in protein. O. sanctum showed superior iron content than the other species. Total phenolic and cardiac glycoside contents of the three leaves were very similar but they showed significant variations in their saponins, tannins, flavonoids and alkaloid contents. PCA revealed that Indian accessions of O. sanctum and O. gratissimum are distinctly separated and different from Nigerian accession of O. gratissimum in morphometric data and phytochemical constituents. Nigerian accession had superior phytochemical contents than the Indian accessions and may be further explored for breeding purposes to complement the Indian accessions for enhanced applications in the pharmaceutical industry in India.
S. Sabiu, E. O. Ajani, R. A. Aladodo, T. Garuba, M. O. Agunbiade, A. A. Alimi, N. Lekena, and M. Abdulrazaq
Springer Science and Business Media LLC
Saheed Sabiu, Taofeeq Garuba, Taofik Olatunde Sunmonu, AbdulHakeem O. Sulyman, and Nurain O. Ismail
Informa UK Limited
Abstract Context: Spondias mombin Linn (Anacardiaceae) and Ficus exasperata Valh (Moraceae) are botanicals with known phytotherapeutic potentials in the traditional system of medicine in the world. Objective: The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats. Materials and methods: Ulceration was induced by a single oral administration of indomethacin (30 mg/kg body weight (b.w.)). Ulcerated rats were orally administered with esomeprazole (a reference drug) at a dose of 20 mg/kg body weight, and Spondias mombin and Ficus exasperata at a dose of 100 and 200 mg/kg b.w. once daily for 21 d after ulcer induction. Gastric secretions and antioxidant parameters were thereafter evaluated. Results: The significantly increased (p < 0.05) ulcer index, gastric volume, malondialdehyde level, and pepsin activity by indomethacin were effectively reduced by 65.40, 36.47, 45.71, and 53.79%, respectively, following treatment with F. exasperata at 200 mg/kg b.w. S. mombin at this regimen also attenuated these parameters by 71.70, 46.62, 50.16, and 55.73%. Moreover, the extracts significantly increase the reduced activity of superoxide dismutase as well as pH and mucin content in the ulcerated rats. Discussion and conclusion: These findings are indicative of gastroprotective and antioxidative potentials of the extracts which is also evident in the degree of % inhibition against ulceration. The available data in this study suggest that the extracts proved to be capable of ameliorating indomethacin-induced gastric ulceration and the probable mechanisms are via antioxidative and proton pump inhibition.
Saheed Sabiu, Taofeeq Garuba, Taofik Sunmonu, Emmanuel Ajani, Abdulhakeem Sulyman, Ismaila Nurain, and Abdulazeez Balogun
Elsevier BV